Lipid Zyme supplies lipase, protease, bromelain, serrapeptase and nattokinase, with fucoxanthin and piperine, in phthalate-free enteric vegicaps, taken between meals.

Directions: 1 capsule 1 to 3 times daily between meals, or as guided.

Each phthalate-free enteric vegicap of Lipid Zyme supplies:

Alkaloid:

 Black Pepper: Piperine (Piper nigrum) 3 mg

“Piper nigrum, significantly enhances the bioavailability of various nutrients through increased absorption. Piperine does this by inhibiting enzymes that metabolize drugs and nutritional substances, stimulating amino acid transporters in the intestinal lining, inhibiting P‑glycoprotein, and decreasing intestinal production of glucuronic acid.” Source: Piperine, Black Pepper (Piper nigrum)

Lipid Mobilizing Carotenoid:

 Kelp: Fucoxanthin 85% (Laminaria spp.) 3.1 mg

"Marked oxidative stress, inflammation, and phagocytosis disruption were evident in differentiated RPE cells following their exposure to visible light under a docosahexaenoic acid (DHA)-rich environment. Following pretreatment with fucoxanthin, however, the activated nuclear factor erythroid-derived-2-like 2 (Nrf2) signaling pathway was observed and, furthermore, when the fucoxanthin-pretreated RPE cells were irradiated with visible light, intracellular reactive oxygen species (ROS), malondialdehyde (MDA) levels and inflammation were obviously suppressed, while phagocytosis was significantly improved."

Article Title: Fucoxanthin Pretreatment Ameliorates Visible Light-Induced Phagocytosis Disruption of RPE Cells under a Lipid-Rich Environment via the Nrf2 Pathway

Publication: Marine Drugs

Link: https://www.mdpi.com/1660-3397/20/1/15

"Due to their abundance of PUFAs [polyunsaturated fatty acids], lipid peroxidation of POSs [photoreceptor outer segments] occurs before being swallowed in the presence of light exposure. Given the close contact between RPE and POSs, this lipid peroxidation appears to be an important cause of visible light-induced damage to RPE cells. The results of this present study further confirmed that under the condition of visible light plus DHA exposure, obvious oxidative injury occurred in the RPE cells... [Fucoxanthin] can effectively inhibit oxidative stress and inflammation induced by visible light plus DHA in RPE cells."

Article Title: Fucoxanthin Pretreatment Ameliorates Visible Light-Induced Phagocytosis Disruption of RPE Cells under a Lipid-Rich Environment via the Nrf2 Pathway

Publication: Marine Drugs

Link: https://www.mdpi.com/1660-3397/20/1/15

Enzymes:

 Lipase (120,000 FIP) 165 mg 

 SBO (Soil-Based Organism): Neutral Protease (Bacillus licheniformis) (200,000 FIP) 125 mg 

"Enteric-coated proteolytic enzyme preparations like Wobenzym and Phlogenzym are widely used for the so-called 'systemic enzyme therapy' both in humans and animals. Numerous publications reveal that oral proteolytic enzymes are able to stimulate directly the activity of immune competent cells as well as to increase efficiency of some of their products."

Article Title: Where do the immunostimulatory effects of oral proteolytic enzymes ('systemic enzyme therapy') come from? Microbial proteolysis as a possible starting point
Publication: Medical Hypotheses
Link: https://pubmed.ncbi.nlm.nih.gov/16870353/

 Bromelain 2,400 GDU/g (Ananas comosus) 150 mg (360 GDU)

 Serrapeptase 400,000 u/g (Serratia marcescens) 17 mg

Serrapeptase degrades non‑living protein and fibrin.

 Nattokinase 20,000 FU/g (Bacillus subtilis) 33 mg