Cinnamon Blue combines aromatic and flavorful Cinnamon Polyphenols with Methylene Blue (MeBlu).

Methylene Blue Background:

Methylene Blue is on the World Health Organization's list of essential medicines.

Methylene Blue was discovered in 1876 and was first used as a dye for cloth.

In medical science, it was noticed that staining pathogens with a dye could kill them.

Methylene Blue was the first synthetic pharmaceutical, first used as a medicine in 1891 through the work of Nobel Prize-winning physician Paul Ehrlich.

Each drop of Cinnamon Blue supplies:

Methylene Blue 400 mcg *

Polyphenols 30% (Cinnamomum cassia) (bark) 400 mcg *

Sodium Benzoate has been used in combination with Methylene Blue to support the maintenance of optimum weight.

We prefer to use Cinnamon as a botanical source of the Benzoate-related compound Cinnamic Acid for similar benefits as well as its enhanced gustatory and olfactory stimulation.

Cinnamon is widely studied for healthy blood sugar regulation. Those studies used 120 mg to 6 g of cinnamon a day. Ten drops of Cinnamon Blue provide 4 mg. Here cinnamon brings aroma, flavor and cinnamic acid.

Reference: Allen RW et al. Cinnamon use in type 2 diabetes: an updated systematic review and meta-analysis. Ann Fam Med 2013.

https://pubmed.ncbi.nlm.nih.gov/24019277/

Nootropic Effects:

Dr. Ehrlich noted that Methylene Blue concentrates in the brain.

Many people are using it for brain-boosting and anti-aging benefits.

It is used as a nootropic to improve memory, mood, and longevity.

Methylene Blue crosses the blood-brain barrier providing neuroprotection and nootropic effects while increasing cerebral blood flow.

Methylene Blue benefits:

 Increases Mitochondrial Complex IV by 30%.

 Increases neurotransmitter levels of catecholamines, acetylcholine (by inhibiting Acetylcholinesterase), serotonin, and norepinephrine (by inhibiting Monoamine-oxidase at higher doses, especially MAO-A).

 Converts the superoxide radical to water, preventing a cascade of other free radicals from ever forming...

 Increases heme synthesis which begins in the mitochondria and affects DNA synthesis as well as transport of Oxygen and electrons.

 Increases cellular Oxygen utilization by 37 to 70% and donates electrons to the electron transport chain, improving mitochondrial metabolism, and increasing the lifespan of brain cells.

Methylene Blue acts as an additional carrier of electrons between NADH and Cytochrome C, essentially hot-wiring this connection in the electron transport chain.

In an animal model, the pesticide Rotenone was used to break that link in the electron transport chain, and Methylene Blue protected the mitochondria from damage by the neurotoxin.

It also reverses premature senescence caused by either Cadmium or Hydrogen Peroxide by preventing telomere shortening.

In an in vitro study of 90-year-old skin cells, the addition of a small dose of Methylene Blue (equivalent to 1-2 mg/day) reverted the cellular metabolism to that of a 20-year-old.

Source:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449383/

Some common observations when taking Methylene Blue include:

 Increased energy and youthful vitality

 Improved sleep

 Better focus of attention

 Enhanced comprehension

 Better short and long-term memory

 Social confidence

 Stress reduction

 Relaxation

Avoid combining Methylene Blue with pharmaceutical antidepressants and antianxiety drugs that affect dopamine or serotonin, including SSRIs and MAOIs like citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline, zimelidine, bupropion, buspirone, clomipramine, mirtazapine, and venlafaxine.

Dosage effects show hormesis, with effects of low doses being opposite those at high doses. Side effects are rare with adult dosages under about 100 mg/day.

Reported side effects with higher doses include stomach pain, chest pain, dizziness, headache, sweating, confusion, high blood pressure, shortness of breath, accelerated heartbeat, tremor, skin turning blue, urine turning blue or green, reduction of red blood cells, or jaundice (only reported in infants).

Methylene Blue has been used as a broad-spectrum antiviral for inactivating viruses in the blood prior to use in transfusion since 1991.